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Very little was previously known about how the carboxymethylated DNA lesions perturb DNA replication in human cells.Here, we investigated the effects of five carboxymethyla...Read More Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and their associated cas genes are sequence-specific DNA nuclease systems found in bacteria and archaea.CRISPR/Cas systems use RNA transcripts of previously acquired DNA (spacers) to target invading genetic elements with the same sequence, including plasmids. Read More In the past decade, molecular surveys of viral diversity have revealed that viruses are the most diverse and abundant biological entities on Earth.Read More Dorr Casey R Remmel Rory P Muthusamy Amutha Fisher James Moriarity Branden Yasuda Kazuto Wu Baolin Guan Weihua Schuetz Erin G Oetting William S Jacobson Pamala A Israni Ajay K Drug Metabolism and Disposition 2017-05-01CRISPR/Cas9 engineering of the CYP3A5 *3 locus (rs776746) in human liver cell line Hu H-7 (CYP3A5 *3/*3) led to three CYP3A5 *1 cell lines by deletion of the exon 3B splice junction or point mutation.Cell lines CYP3A5 *1/*3 sd (single deletion), CYP3A5 *1/*1 dd (double deletion) or CYP3A5 *1/*3 pm (point mutation) expressed the ...Read More In vivo application of the CRISPR-Cas9 technology is still limited by unwanted Cas9 genomic cleavages.Long-term expression of Cas9 increases the number of genomic loci non-specifically cleaved by the nuclease.

Read More Metzakopian Emmanouil Strong Alex Iyer Vivek Hodgkins Alex Tzelepis Konstantinos Antunes Liliana Friedrich Mathias J Kang Qiaohua Davidson Teresa Lamberth Jacob Hoffmann Christina Davis Gregory D Vassiliou George S Skarnes William C Bradley Allan Scientific reports 2017-05-01CRISPR-Cas9 technology has accelerated biological research becoming routine for many laboratories.

Recently, CRISPR-CRISPR from Prevotella and Francisella 1 (Cpf1) has emerged as a new tool for efficient genome editing, including D...

Read More Metabolic activation of some N-nitroso compounds (NOCs), an important class of DNA damaging agents, can induce the carboxymethylation of nucleobases in DNA.

Directed by programmable sequence-specific RNAs, this system introduces cleavage and double-stranded breaks at target sites precisely. Read More CRISPR/Cas9 is a versatile genome-editing tool which is widely used for modifying the genome of both prokaryotic and eukaryotic organisms for basic research and applications.

An increasing number of reports have demonstrated that CRISPR/Cas9-mediated genome editing is a powerful technology for gene therapy. Read More Learning how to actively avoid a predictable threat involves two steps: recognizing the cue that predicts upcoming punishment and learning a behavioral response that will lead to avoidance.

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